What is IGF-1?

Steroid Profiles ». IGF. Insulin-Like Growth Factor-1, commonly referred to as IGF-1 is a polypeptide hormone that belongs to the growth factor hormone family. This is a naturally produced hormone in all human beings with production primarily occurring in the liver, and to a degree in the peripheral tissues.

What is the IGF axis called?

IGF1/GH axis The IGF axis is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1, or sometimes with a Roman numeral as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH).

What role do IGFs play in cancer?

Other studies are beginning to uncover the important role the IGFs play in diseases such as cancer and diabetes, showing for instance that IGF-1 stimulates growth of both prostate and breast cancer cells. Researchers are not in complete agreement about the degree of cancer risk that IGF-1 poses.

What is insulin-like growth factor (IGF)?

Insulin-like growth factor. The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF axis) consists of two cell-surface receptors (IGF1R and IGF2R),...

What is IGF-1 test?

This test measures the amount of IGF-1 (insulin-like growth factor 1) in your blood. IGF-1 is a hormone that manages the effects of growth hormone (GH) in your body. Together, IGF-1 and GH promote normal growth of bones and tissues.

What does IGF mean?

IGF is known as a growth factor and is part of a group of tissue and cell-building hormones that also includes epidermal growth factor, platelet-derived growth factor and nerve growth factor. On one hand, IGF-1 possesses certain anti-aging and performance-boosting effects — including helping to build and retain muscle mass and bone mass.

Is IGF-1 the “real” growth hormone?

Paracrine insulin-like growth factor 1 (IGF-1) secretion and endocrine IGF-1 targets in the various zones of the epiphyseal cartilage growth zone. The following is an analysis of whether IGF-1, the anabolic effector hormone of pituitary GH, is the “real growth hormone”. Is IGF-1 “a” or “the” growth hormone?

What is the binding protein for IGF 1?

Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by insulin. IGF-1 is produced throughout life; the highest rates of IGF-1 production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age.

Do IGFs play a role in cancer risk?

More recently, evidence has accrued to demonstrate that the IGFs play an important role in cancer. Individuals with serum IGF-II levels in the upper quartile of the normal range (and IGF binding protein-3 levels in the lower quartiles) have a relative risk for developing breast, prostate, colon and lung cancer.

How do insulin-like growth factors (IGFs) work?

Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. The IGFs actions are mediated through the IGF-1 receptor that is involved in cell transformation induced by tumour.

What is the role of IGF-1 in the pathophysiology of pancreatic cancer?

Ma J, et al. IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells. J Surg Res. 2010;160(1):90–101.

How is the IGF system involved in glioblastoma tumor invasion?

Taken together with the observation that tumor cells within the margins of infiltration express higher levels of IGF-1R [104], the IGF system is intimately linked to glioblastoma tumor invasion.

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